Endocrine Abstracts

Introduction: Luteinizning hormone (LH/hCG) responsiveness has been documented in both normal and pathological adrenal glands, but it is unclear whether chronic exposure to LH could affect adrenal function by increasing LH receptor (LHR) expression.Subjects and methods: We studied 12 postmenopausal women with previously documented adrenal tumor. All patients underwent standard hormonal testing for assessment of tumor functionality. Then hCG test was perf...

Adrenocortical carcinoma (ACC) is rare malignancy associated with poor prognosis. The aim of this study was to present clinical characteristics and survival of patients with ACC and to analyse the effect of prognostic factors on survival.We retrospectively analysed 69 patients (46 female and 23 males) with pathologically confirmed ACC who were treated in our hospital between January 2005 and December 2015. The median age at diagnosis was 51,0 years (rang...

Introduction: Dyslipidaemia is a common metabolic derangement in polycystic ovary syndrome (PCOS) and may be represented with different lipid alterations. The aim of this study was to evaluate lipid profile in different PCOS phenotypes.Methods: We evaluated 365 PCOS women (PCOS: 25.05±6.24 kg/m2; 25.48±5.21 years) diagnosed using ESHRE/ASRM criteria and 125 BMI-matched healthy women (controls: 25.41±5.16 kg/m2; 30.35&...

Introduction: Insulin resistance and obesity are common features of polycystic ovary syndrome (PCOS) and both are independently associated with dysglycaemia. The aim of this study was to determine prevalence of dysglycaemia in obese women with PCOS.Methods: PCOS was diagnosed using ESHRE/ASRM criteria. Obesity was defined as BMI ≥25 kg/m2. We evaluated 100 obese women with PCOS (PCOS group: 28.99±3.05 kg/m2; 27.70±5....

Polycystic ovary syndrome (PCOS) is a complex reproductive disorder that is usually associated with metabolic disturbances such as obesity, dyslipidemia and insulin resistance. In this study, female rats treated with nonaromatizable 5α dihydrotestosterone (DHT) were used as an animal model of PCOS. The aim of this study was to assess the presence of inflammation in liver and visceral adipose tissue (VAT), which accompanies metabolic disturbances in animal model of PCOS. F...

The clear cell renal cell carcinoma (ccRCC) can be sporadic or familiar, with the mutated von Hippel-Lindau (VHL) gene. The inactive VHL protein prevents degradation of hypoxia inducible factor (HIF) that promotes overexpression of angiogenic factors such as vascular endothelial growth factor (VEGF) and erythropoietin (EPO). Sequencing and multiplex ligation-dependent probe amplification (MLPA) of VHL gene in 43 samples of ccRCC in tumors vs surrounding healthy tissues reveale...

Introduction: Chromogranin A (CgA) is a major representative of the protein family named granins stored predominately in secretory granules of the diffuse neuroendocrine system. Circulating CgA serves as a biomarker of neuroendocrine tumors (NETs), but its increased plasma concentration is present in various cardiovascular, gastrointestinal, renal and inflammatory diseases. Intra-granular and/or extracellular proteolysis of CgA generates a variety of biologically active fragme...

Ghrelin is a somatotrophic, orexigenic and adipogenic hormone that has an important homeostatic role by linking regulatory systems for growth and energy balance. Ghrelin- secreting neuroendocrine tumors are rare, but we had the opportunity to study a 71 years old female patient with a gastric ghrelinoma. The patient was submitted to gastroenterological examination after having episodes of diarrhea, and small subepithelial polyp (5 mm) was revealed on gastroscopy. Pathohystolog...

Cortisol rise during pregnancy is connected with fetal maturation. Together with the increase of insulin resistance it might have a role in allocation of nutrients between mother and fetus. Cortisol and insulin secretion during pregnancy seems to be induced by fluctuations in BMR. Here, we try to identify relationship between BMR and secretion of cortisol and insulin during pregnancy.In 25 healthy women (age range 20–39 years; mean±S.D.<...

A 34 year-old female patient was admitted to the hospital because of a large nodule in the left thyroid lobe and elevated calcitonine level. A large encapsulated tumor was found and total thyroidectomy with left neck dissection was performed. Pathohistology revealed medullary and papillary carcinoma separate from each other in tumor tissue but mixed in regional lymph nodes. Papillary component was dominant in thyroid tissue but not in lymph nodes. Both calcitonine and thyroglo...